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Furthermore, significantly elevated branch-chain fatty acids (BCFA), which are metabolic products of protein breakdown have been hypothesized to induce epithelium inflammation ( These microbial alterations coincided with PTSD symptomatology, BBB dysfunction and hippocampal neuroinflammation, which was confirmed by increased proinflammatory cytokine levels IL-1 and IL-6 (Tanelian et al., 2023)

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Intravenous administration in healthy adults showed excellent tolerability, with no adverse effects on cardiac, hepatic, renal, or thyroid biomarkers at doses up to 20 mg